Biomarkers such as proteins are naturally occurring biomolecules useful for measuring the prognosis and/or progress of diseases and therapies. They are normally present in small amounts in the blood or tissues. When the amounts of these molecules change, they may indicate disease. Poochon developed a reliable platform “PROMIC” and a novel proteomic pathway analysis tool “PROMICPATH” for quantitative global protein profiling and proteomic pathway analysis, which is an ideal combination to differentiate disease and normal samples for biomarker discovery.